The Lux Bio + Tech Index

Index overview
3 months
  • TickerLUXBT
  • Inception Date04/26/2021
  • WeightingEqual
  • Number of holdings67

Developed by Lux Capital, the Lux Bio + Tech Index™ is a secular investment theme that covers companies innovating to further the molecular understanding of the "omics stack" to companies building "operating systems" for the future of drug discovery and ultimately even drug development. Over time these companies have transformed from radical, even heretical, ideas to undeniable technical, scientific, and clinical proof points. The last decade has ushered in an unparalleled understanding of the molecular basis of biology, enabled by emergent tool kits to engineer and perturb biology, ultimately increasing the velocity of discovery. Today, Moore's Law-like cost curves exist along many axes in biotech and have given rise to an era of precise, high fidelity, large scale, highly reproducible, and increasingly automated biological and chemical experimentation and discovery. The modern scientist-entrepreneur not only sits at the wetbench but also has proficiency to deconvolute high dimensional and historically unmanageable data with GPUs, the cloud, and the array of advances from machine learning and deep learning.

Full methodology


The Lux Bio + Tech Index

Quick stats

What's inside?
Top 10 holdings
Company% of Index
1Nuvalent, Inc. (NUVL)8.02%
2DiCE Therapeutics, Inc (DICE)4.35%
3Dyne Therapeutics, Inc. (DYN)3.61%
4Olink Holding AB (OLK)3.37%
5Entrada Therapeutics, Inc. (TRDA)3.21%
6Ionis Pharmaceuticals, Inc. (IONS)3.06%
7Alnylam Pharmaceuticals, Inc. (ALNY)3.00%
8SAGE Therapeutics, Inc. (SAGE)2.81%
9Regeneron Pharmaceuticals, Inc. (REGN)2.72%
104D Molecular Therapeutics, Inc. (FDMT)2.72%


All holdings as of May 31, 2023
CSV download
Nuvalent, Inc. (NUVL)8.02%$2.392BN/AN/AN/A
DiCE Therapeutics, Inc (DICE)4.35%$1.509BN/AN/AN/A
Dyne Therapeutics, Inc. (DYN)3.61%$0.760BN/AN/AN/A
Olink Holding AB (OLK)3.37%$2.403B21.57%64.15%18.06x
Entrada Therapeutics, Inc. (TRDA)3.21%$0.380BN/A97.86%2.93x
Ionis Pharmaceuticals, Inc. (IONS)3.06%$5.852B-8.03%94.68%8.04x
Alnylam Pharmaceuticals, Inc. (ALNY)3.00%$23.039B49.72%82.82%22.23x
SAGE Therapeutics, Inc. (SAGE)2.81%$2.958B108.22%83.21%147.33x
Regeneron Pharmaceuticals, Inc. (REGN)2.72%$80.685B6.64%82.39%7.07x
4D Molecular Therapeutics, Inc. (FDMT)2.72%$0.769B-75.55%-373.83%171.16x
BridgeBio Pharma, Inc. (BBIO)2.66%$2.202B7.79%7.78%48.28x
Schrödinger, Inc. (SDGR)2.66%$2.393B33.12%70.53%7.75x
CRISPR Therapeutics AG (CRSP)2.24%$5.055B10,538.30%52.76%19.11x
Denali Therapeutics, Inc. (DNLI)2.18%$4.137B-16.61%73.91%18.87x
Certara, Inc. (CERT)1.84%$3.321B10.73%49.28%11.35x
Janux Therapeutics, Inc. (JANX)1.79%$0.486B28.89%77.88%23.59x
Kymera Therapeutics, Inc. (KYMR)1.73%$1.628B-1.62%90.49%29.91x
Vir Biotechnology, Inc. (VIR)1.73%$3.573B-94.89%84.56%2.19x
Ultragenyx Pharmaceutical, Inc. (RARE)1.69%$3.495B25.72%83.29%8.10x
Recursion Pharmaceuticals, Inc. (RXRX)1.63%$1.687B127.53%-3.84%18.37x
AbCellera Biologics, Inc. (ABCL)1.63%$2.012B-96.15%N/A7.91x
Nautilus Biotechnology, Inc. (NAUT)1.61%$0.357BN/AN/AN/A
Moderna, Inc. (MRNA)1.57%$48.684B-69.10%53.48%3.64x
Seres Therapeutics, Inc. (MCRB)1.53%$0.633B-134.96%N/A150.56x
BioNTech SE (BNTX)1.44%$25.323B-80.84%92.48%1.35x
Sana Biotechnology, Inc. (SANA)1.42%$1.153BN/AN/AN/A
10X Genomics, Inc. (TXG)1.37%$6.095B17.28%68.44%11.44x
Stoke Therapeutics, Inc. (STOK)1.36%$0.495B71.73%77.74%7.22x
Evotec SE (EVO)1.29%$3.843B14.82%34.26%3.34x
Lyell Immunopharma, Inc. (LYEL)1.26%$0.796B-88.25%-7,633.85%0.51x
Generation Bio Co. (GBIO)1.23%$0.230BN/AN/AN/A
Monte Rosa Therapeutics, Inc. (GLUE)1.22%$0.364BN/AN/AN/A
Centessa Pharmaceuticals Plc (CNTA)1.21%$0.429BN/AN/AN/A
Nurix Therapeutics, Inc. (NRIX)1.18%$0.480B31.85%74.93%5.83x
Beam Therapeutics, Inc. (BEAM)1.17%$2.431B187.10%71.08%17.37x
Verve Therapeutics, Inc. (VERV)1.14%$0.959BN/A-96.51%138.24x
Akoya Biosciences, Inc. (AKYA)1.11%$0.216B26.73%48.21%4.14x
Alector, Inc. (ALEC)1.08%$0.620B-32.38%87.30%-0.90x
Relay Therapeutics, Inc. (RLAY)1.07%$1.355B-46.06%-429.65%940.32x
Editas Medicine, Inc. (EDIT)1.06%$0.633B45.49%84.33%9.58x
Intellia Therapeutics, Inc. (NTLA)1.00%$3.284B12.03%83.74%46.07x
Compass Pathways Plc (CMPS)0.98%$0.314BN/AN/AN/A
Nkarta, Inc. (NKTX)0.93%$0.226BN/AN/AN/A
Caribou Biosciences, Inc. (CRBU)0.93%$0.271B31.46%68.48%8.43x
Adaptive Biotechnologies Corp. (ADPT)0.92%$1.004B-2.52%35.97%5.75x
Exscientia Plc (EXAI)0.87%$0.952B-25.16%-101.20%3.96x
SomaLogic, Inc. (SLGC)0.83%$0.569B-11.32%39.57%-0.23x
Graphite Bio, Inc. (GRPH)0.78%$0.165BN/AN/AN/A
Arvinas, Inc. (ARVN)0.78%$1.166B34.30%94.77%2.51x
ATAI Life Sciences NV (ATAI)0.77%$0.297BN/A-351.35%195.63x
Tango Therapeutics, Inc. (TNGX)0.76%$0.239B0.14%74.71%2.26x
Invivyd, Inc. (ADGI)0.76%$0.197BN/AN/AN/A
Ginkgo Bioworks Holdings, Inc. (DNA)0.69%$3.067B-52.08%48.78%4.46x
Nuvation Bio, Inc. (NUVB)0.68%$0.356BN/AN/AN/A
Absci Corp. (ABSI)0.68%$0.176B54.95%-176.12%3.56x
Quantum-Si, Inc. (QSI)0.65%$0.214BN/A-478.35%-230.30x
Century Therapeutics, Inc. (IPSC)0.56%$0.189B62.57%-26.16%0.67x
Seer, Inc. (California) (SEER)0.56%$0.235B22.37%18.80%-4.97x
Erasca, Inc. (ERAS)0.51%$0.409BN/AN/AN/A
Celularity, Inc. (CELU)0.46%$0.137B-33.70%-10.95%9.48x
Passage Bio, Inc. (PASG)0.44%$0.052BN/AN/AN/A
Quince Therapeutics, Inc. (CRTX)0.42%$0.054BN/AN/AN/A
C4 Therapeutics, Inc. (CCCC)0.32%$0.166B-50.89%45.14%-1.14x
Fate Therapeutics, Inc. (FATE)0.29%$0.497B220.30%92.89%1.88x
Taysha Gene Therapies, Inc. (TSHA)0.20%$0.045BN/A86.59%6.50x
PhenomeX, Inc. (BLI)0.18%$0.069B-23.05%67.28%1.33x
Finch Therapeutics Group, Inc. (FNCH)0.08%$0.013B-69.77%-1,177.57%21.74x
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