The Lux Bio + Tech Index

Index Overview
3 Months
  • TickerLUXBT
  • Inception Date04/26/2021
  • WeightingEqual
  • Number of holdings67

Developed by Lux Capital, the Lux Bio + Tech Index™ is a secular investment theme that covers companies innovating to further the molecular understanding of the "omics stack" to companies building "operating systems" for the future of drug discovery and ultimately even drug development. Over time these companies have transformed from radical, even heretical, ideas to undeniable technical, scientific, and clinical proof points. The last decade has ushered in an unparalleled understanding of the molecular basis of biology, enabled by emergent tool kits to engineer and perturb biology, ultimately increasing the velocity of discovery. Today, Moore's Law-like cost curves exist along many axes in biotech and have given rise to an era of precise, high fidelity, large scale, highly reproducible, and increasingly automated biological and chemical experimentation and discovery. The modern scientist-entrepreneur not only sits at the wetbench but also has proficiency to deconvolute high dimensional and historically unmanageable data with GPUs, the cloud, and the array of advances from machine learning and deep learning.

Full Methodology


The Lux Bio + Tech Index



Quick Stats

What's inside?
Top 10 Holdings
Company% of Index
1Nuvalent, Inc. (NUVL)5.67%
2DiCE Therapeutics, Inc (DICE)4.25%
3Entrada Therapeutics, Inc. (TRDA)4.18%
4Olink Holding AB (OLK)3.84%
5Alnylam Pharmaceuticals, Inc. (ALNY)3.14%
6Dyne Therapeutics, Inc. (DYN)2.95%
74D Molecular Therapeutics, Inc. (FDMT)2.78%
8AbCellera Biologics, Inc. (ABCL)2.50%
9Regeneron Pharmaceuticals, Inc. (REGN)2.48%
10Ionis Pharmaceuticals, Inc. (IONS)2.42%


All Holdings as of December 2, 2022
CSV download
Nuvalent, Inc. (NUVL)5.67%$2.034BN/AN/AN/A
DiCE Therapeutics, Inc (DICE)4.25%$1.393BN/AN/AN/A
Entrada Therapeutics, Inc. (TRDA)4.18%$0.574BN/AN/AN/A
Olink Holding AB (OLK)3.84%$2.918B58.18%66.06%11.03x
Alnylam Pharmaceuticals, Inc. (ALNY)3.14%$28.838B40.86%84.44%25.79x
Dyne Therapeutics, Inc. (DYN)2.95%$0.620BN/AN/AN/A
4D Molecular Therapeutics, Inc. (FDMT)2.78%$0.734B-63.40%N/AN/A
AbCellera Biologics, Inc. (ABCL)2.50%$3.636B1,740.65%N/A3.82x
Regeneron Pharmaceuticals, Inc. (REGN)2.48%$83.448B-14.96%86.02%5.35x
Ionis Pharmaceuticals, Inc. (IONS)2.42%$5.727B20.04%95.86%6.34x
Akoya Biosciences, Inc. (AKYA)2.14%$0.488B39.89%48.23%6.15x
SAGE Therapeutics, Inc. (SAGE)2.02%$2.595B20.76%73.43%146.56x
Denali Therapeutics, Inc. (DNLI)1.89%$4.432B-32.66%64.15%24.80x
BioNTech SE (BNTX)1.86%$41.193B-51.44%78.25%1.06x
Moderna, Inc. (MRNA)1.84%$70.055B-33.31%63.40%1.96x
Tango Therapeutics, Inc. (TNGX)1.84%$0.700B1.96%82.37%-1.45x
Seres Therapeutics, Inc. (MCRB)1.76%$0.888B-97.28%12.89%47.08x
Janux Therapeutics, Inc. (JANX)1.75%$0.568B56.43%86.27%33.54x
Generation Bio Co. (GBIO)1.72%$0.356BN/AN/AN/A
Caribou Biosciences, Inc. (CRBU)1.69%$0.586B-16.95%67.54%29.63x
CRISPR Therapeutics AG (CRSP)1.62%$4.267B-88.59%-5,238.30%244.47x
Kymera Therapeutics, Inc. (KYMR)1.52%$1.689B-53.03%91.62%15.71x
Century Therapeutics, Inc. (IPSC)1.50%$0.643BN/A-24.73%56.60x
BridgeBio Pharma, Inc. (BBIO)1.50%$1.416B-85.58%-427.81%29.35x
Vir Biotechnology, Inc. (VIR)1.46%$3.675B261.49%93.61%0.16x
Verve Therapeutics, Inc. (VERV)1.45%$1.478BN/A-114.96%1,608.47x
Relay Therapeutics, Inc. (RLAY)1.43%$2.269B-48.35%-200.29%877.55x
Beam Therapeutics, Inc. (BEAM)1.40%$3.299B1,970.64%64.45%26.48x
Nkarta, Inc. (NKTX)1.40%$0.419BN/AN/AN/A
Monte Rosa Therapeutics, Inc. (GLUE)1.34%$0.470BN/AN/AN/A
Recursion Pharmaceuticals, Inc. (RXRX)1.34%$1.765B419.34%-17.67%50.20x
Lyell Immunopharma, Inc. (LYEL)1.32%$1.005B-99.89%-138,966.67%31.61x
Certara, Inc. (CERT)1.29%$2.789B14.55%48.26%6.82x
Compass Pathways Plc (CMPS)1.28%$0.477BN/AN/AN/A
Arvinas, Inc. (ARVN)1.24%$2.203B226.34%93.07%9.78x
ATAI Life Sciences NV (ATAI)1.22%$0.589B-90.98%-50.00%556.59x
Erasca, Inc. (ERAS)1.21%$0.931BN/AN/AN/A
Ultragenyx Pharmaceutical, Inc. (RARE)1.14%$2.816B11.09%85.31%8.47x
Schrödinger, Inc. (SDGR)1.13%$1.236B23.89%46.51%8.19x
Nurix Therapeutics, Inc. (NRIX)1.12%$0.595B5.26%73.26%11.95x
Alector, Inc. (ALEC)1.07%$0.753B-91.86%86.24%0.51x
Intellia Therapeutics, Inc. (NTLA)1.03%$3.629B84.15%85.30%68.58x
Fate Therapeutics, Inc. (FATE)1.00%$2.032B5.31%78.69%25.79x
Adaptive Biotechnologies Corp. (ADPT)0.97%$1.281B21.19%57.58%4.42x
Editas Medicine, Inc. (EDIT)0.95%$0.705B-99.32%-3,719.05%17.28x
Evotec SE (EVO)0.94%$3.230B-6.98%16.34%3.68x
Centessa Pharmaceuticals Plc (CNTA)0.89%$0.365BN/AN/AN/A
Quantum-Si, Inc. (QSI)0.88%$0.348BN/AN/AN/A
Invivyd, Inc. (ADGI)0.85%$0.253BN/AN/AN/A
Sana Biotechnology, Inc. (SANA)0.83%$0.864BN/AN/AN/A
Absci Corp. (ABSI)0.82%$0.245B53.93%-43.69%19.67x
Celularity, Inc. (CELU)0.81%$0.254B-61.07%-132.33%19.91x
Nautilus Biotechnology, Inc. (NAUT)0.81%$0.222BN/AN/AN/A
10X Genomics, Inc. (TXG)0.80%$4.461B4.61%72.13%5.74x
Stoke Therapeutics, Inc. (STOK)0.76%$0.290BN/A68.19%28.47x
Seer, Inc. (California) (SEER)0.76%$0.442B84.38%22.30%5.59x
Graphite Bio, Inc. (GRPH)0.73%$0.204BN/AN/AN/A
Ginkgo Bioworks Holdings, Inc. (DNA)0.71%$3.463B-14.45%48.55%7.28x
Berkeley Lights, Inc. (BLI)0.70%$0.216B-12.03%70.22%1.28x
Nuvation Bio, Inc. (NUVB)0.70%$0.437BN/AN/AN/A
Exscientia Plc (EXAI)0.66%$0.754B-69.54%-86.23%12.41x
SomaLogic, Inc. (SLGC)0.66%$0.544B108.65%72.02%-0.26x
C4 Therapeutics, Inc. (CCCC)0.66%$0.419B-20.54%71.59%4.21x
Taysha Gene Therapies, Inc. (TSHA)0.55%$0.147BN/AN/AN/A
Passage Bio, Inc. (PASG)0.46%$0.067BN/AN/AN/A
Finch Therapeutics Group, Inc. (FNCH)0.23%$0.046B-98.78%-918.12%28.19x
Quince Therapeutics, Inc. (CRTX)0.17%$0.026BN/AN/AN/A
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