| ProQR Therapeutics NV (PRQR) | 2.47% | $353.68M | 417.56% | 88.72% | 3.09 |
| aTyr Pharma, Inc. (LIFE) | 1.62% | $226.63M | N/A | N/A | 81.55 |
| CorMedix, Inc. (CRMD) | 1.47% | $635.95M | N/A | 36.75% | 253.66 |
| Kodiak Sciences, Inc. (KOD) | 1.36% | $190.47M | N/A | N/A | N/A |
| Neoleukin Therapeutics, Inc. (NLTX) | 1.32% | $706.61M | N/A | 11.68% | 515.01 |
| Voyager Therapeutics, Inc. (VYGR) | 1.28% | $440.08M | 509.48% | 95.29% | 0.92 |
| Ocular Therapeutix, Inc. (OCUL) | 1.25% | $1.77B | 8.26% | 90.82% | 12.27 |
| Delcath Systems, Inc. (DCTH) | 1.24% | $315.85M | 1,468.89% | 80.44% | 18.78 |
| Lexicon Pharmaceuticals, Inc. (LXRX) | 1.24% | $751.90M | 419.56% | 81.48% | 87.32 |
| electroCore, Inc. (ECOR) | 1.23% | $51.83M | 72.88% | 86.35% | 1.64 |
| Allakos, Inc. (ALLK) | 1.20% | $58.64M | N/A | N/A | N/A |
| Esperion Therapeutics, Inc. (ESPR) | 1.20% | $400.30M | 186.33% | 78.85% | 2.83 |
| Atara Biotherapeutics, Inc. (ATRA) | 1.19% | $53.39M | 2,892.69% | 83.84% | 1.71 |
| KalVista Pharmaceuticals, Inc. (KALV) | 1.18% | $540.19M | N/A | N/A | N/A |
| Karyopharm Therapeutics, Inc. (KPTI) | 1.17% | $108.49M | 13.86% | 96.36% | 1.22 |
| Accelerate Diagnostics, Inc. (AXDX) | 1.16% | $42.86M | 2.23% | 22.64% | 4.88 |
| Daré Bioscience, Inc. (DARE) | 1.13% | $31.88M | N/A | 31.20% | 8.31 |
| Acumen Pharmaceuticals, Inc. (ABOS) | 1.13% | $171.83M | N/A | N/A | N/A |
| Adverum Biotechnologies, Inc. (ADVM) | 1.12% | $176.39M | N/A | N/A | N/A |
| VYNE Therapeutics, Inc. (VYNE) | 1.10% | $32.67M | 46.67% | N/A | 12.12 |
| XBiotech, Inc. (XBIT) | 1.10% | $230.00M | N/A | N/A | N/A |
| Abeona Therapeutics, Inc. (ABEO) | 1.09% | $288.91M | -100.00% | N/A | N/A |
| Mind Medicine (MindMed), Inc. (MNMD) | 1.09% | $537.79M | N/A | N/A | N/A |
| Achieve Life Sciences, Inc. (ACHV) | 1.09% | $174.45M | N/A | N/A | N/A |
| Rigel Pharmaceuticals, Inc. (RIGL) | 1.09% | $265.86M | 37.03% | 92.38% | 1.19 |
| Larimar Therapeutics, Inc. (LRMR) | 1.08% | $495.14M | N/A | N/A | N/A |
| Aadi Bioscience, Inc. (AADI) | 1.08% | $51.94M | -0.37% | 87.41% | -1.36 |
| Annovis Bio, Inc. (ANVS) | 1.07% | $120.23M | N/A | N/A | N/A |
| Nektar Therapeutics (NKTR) | 1.07% | $259.55M | 14.59% | 58.53% | 2.23 |
| Cardiff Oncology, Inc. (CRDF) | 1.07% | $134.99M | 50.93% | 35.58% | 61.71 |
| Vanda Pharmaceuticals, Inc. (VNDA) | 1.05% | $286.20M | 9.59% | 91.11% | -0.28 |
| Annexon, Inc. (ANNX) | 1.05% | $790.29M | N/A | N/A | N/A |
| Vivani Medical, Inc. (EYES) | 1.04% | $71.83M | N/A | N/A | N/A |
| PMV Pharmaceuticals, Inc. (PMVP) | 1.04% | $81.40M | N/A | N/A | N/A |
| DiaMedica Therapeutics, Inc. (DMAC) | 1.04% | $185.53M | N/A | N/A | N/A |
| SELLAS Life Sciences Group, Inc. (SLS) | 1.03% | $81.06M | N/A | N/A | N/A |
| Atea Pharmaceuticals, Inc. (AVIR) | 1.03% | $322.49M | N/A | N/A | N/A |
| IGM Biosciences, Inc. (IGMS) | 1.02% | $567.34M | 179.91% | -81.50% | 67.98 |
| Relmada Therapeutics, Inc. (RLMD) | 1.02% | $108.93M | N/A | N/A | N/A |
| Verastem, Inc. (VSTM) | 1.02% | $119.12M | N/A | 99.94% | 5.97 |
| InflaRx NV (IFRX) | 1.01% | $93.62M | N/A | -5,376.69% | 202.13 |
| SCYNEXIS, Inc. (SCYX) | 1.01% | $60.57M | -99.44% | N/A | 4.05 |
| PDS Biotechnology Corp. (PDSB) | 1.00% | $119.66M | N/A | N/A | N/A |
| Actinium Pharmaceuticals, Inc. (ATNM) | 1.00% | $56.70M | N/A | N/A | 1,710.80 |
| AlloVir, Inc. (ALVR) | 1.00% | $87.67M | N/A | N/A | N/A |
| Cellectar Biosciences, Inc. (CLRB) | 1.00% | $74.92M | N/A | N/A | N/A |
| Enlivex Therapeutics Ltd. (ENLV) | 0.99% | $32.54M | N/A | N/A | N/A |
| Syros Pharmaceuticals, Inc. (SYRS) | 0.99% | $52.55M | -100.00% | N/A | 44.44 |
| Oramed Pharmaceuticals, Inc. (ORMP) | 0.99% | $94.38M | -100.00% | N/A | N/A |
| Cidara Therapeutics, Inc. (CDTX) | 0.99% | $79.25M | -96.03% | 81.13% | -2.70 |
| Carisma Therapeutics, Inc. (SESN) | 0.98% | $40.50M | 158.34% | 97.23% | 1.28 |
| CytomX Therapeutics, Inc. (CTMX) | 0.98% | $92.18M | 1.58% | 98.17% | -0.18 |
| Chimerix, Inc. (CMRX) | 0.98% | $78.97M | 396.15% | 81.40% | -473.23 |
| Sutro Biopharma, Inc. (STRO) | 0.98% | $305.72M | 146.89% | 93.04% | 0.01 |
| Akebia Therapeutics, Inc. (AKBA) | 0.97% | $281.79M | -22.58% | 60.03% | 1.60 |
| VistaGen Therapeutics, Inc. (VTGN) | 0.96% | $83.06M | -52.70% | -79.76% | 0.13 |
| Exagen, Inc. (XGN) | 0.96% | $50.07M | 6.56% | 60.12% | 0.57 |
| Mersana Therapeutics, Inc. (MRSN) | 0.96% | $257.62M | -78.48% | 82.42% | 3.86 |
| Aldeyra Therapeutics, Inc. (ALDX) | 0.96% | $338.70M | N/A | N/A | N/A |
| Leap Therapeutics, Inc. (LPTX) | 0.95% | $102.36M | N/A | N/A | N/A |
| Galectin Therapeutics, Inc. (GALT) | 0.95% | $166.28M | N/A | N/A | N/A |
| Spero Therapeutics, Inc. (SPRO) | 0.95% | $69.18M | 663.58% | 99.97% | 0.11 |
| Sol-Gel Technologies Ltd. (SLGL) | 0.95% | $19.29M | 814.65% | N/A | -0.65 |
| GlycoMimetics, Inc. (GLYC) | 0.95% | $10.21M | N/A | N/A | -377.86 |
| Precigen, Inc. (PGEN) | 0.95% | $274.22M | -59.42% | -209.90% | 87.84 |
| MediciNova, Inc. (MNOV) | 0.94% | $88.77M | N/A | N/A | 26.78 |
| Ocuphire Pharma, Inc. (OCUP) | 0.94% | $34.58M | -69.73% | N/A | -0.12 |
| ESSA Pharma, Inc. (EPIX) | 0.93% | $269.76M | N/A | N/A | N/A |
| Assembly Biosciences, Inc. (ASMB) | 0.93% | $115.74M | N/A | 99.62% | -1.40 |
| SOPHiA GENETICS SA (SOPH) | 0.93% | $234.70M | 5.01% | 68.17% | 3.49 |
| ADC Therapeutics SA (ADCT) | 0.93% | $301.67M | -9.71% | 88.20% | 1.90 |
| Axogen, Inc. (AXGN) | 0.92% | $576.80M | 25.57% | 73.77% | 2.07 |
| Precision BioSciences, Inc. (DTIL) | 0.92% | $64.67M | 152.15% | 97.23% | -0.28 |
| CollPlant Biotechnologies Ltd. (CLGN) | 0.90% | $47.93M | -97.55% | -220.08% | 59.74 |
| Trevi Therapeutics, Inc. (TRVI) | 0.90% | $226.49M | N/A | N/A | N/A |
| Astria Therapeutics, Inc. (ATXS) | 0.90% | $646.63M | N/A | N/A | N/A |
| InspireMD, Inc. (NSPR) | 0.89% | $64.01M | 5.46% | 19.03% | 6.65 |
| Curis, Inc. (CRIS) | 0.88% | $31.63M | 15.89% | 97.09% | 5.29 |
| Minerva Neurosciences, Inc. (NERV) | 0.88% | $17.55M | N/A | N/A | N/A |
| Verrica Pharmaceuticals, Inc. (VRCA) | 0.87% | $68.27M | 2,744.51% | 89.53% | 25.41 |
| CARA Therapeutics, Inc. (CARA) | 0.87% | $14.54M | -85.71% | 92.23% | 0.42 |
| Immunic, Inc. (IMUX) | 0.86% | $143.23M | N/A | N/A | N/A |
| IRIDEX Corp. (IRIX) | 0.86% | $27.28M | -1.74% | 40.00% | 0.67 |
| NeuroPace, Inc. (NPCE) | 0.86% | $188.90M | 16.63% | 73.40% | 3.29 |
| Inovio Pharmaceuticals, Inc. (INO) | 0.86% | $145.66M | -55.41% | -722.36% | 206.67 |
| Anixa Biosciences, Inc. (ANIX) | 0.85% | $96.86M | N/A | N/A | N/A |
| Lyra Therapeutics, Inc. (LYRA) | 0.85% | $15.95M | 30.57% | 75.75% | -6.94 |
| Lifeward Ltd. (RWLK) | 0.85% | $23.60M | 401.65% | 33.65% | 0.89 |
| Cognition Therapeutics, Inc. (CGTX) | 0.84% | $19.84M | N/A | N/A | N/A |
| BioVie, Inc. (BIVI) | 0.84% | $18.76M | N/A | N/A | N/A |
| AC Immune SA (ACIU) | 0.84% | $312.00M | N/A | N/A | 11.81 |
| Ocugen, Inc. (OCGN) | 0.84% | $270.59M | N/A | 49.34% | 109.45 |
| Solid Biosciences, Inc. (SLDB) | 0.83% | $254.73M | N/A | N/A | N/A |
| SIGA Technologies, Inc. (SIGA) | 0.81% | $493.88M | 271.05% | 43.55% | 2.54 |
| Tempest Therapeutics, Inc. (TPST) | 0.81% | $27.73M | N/A | N/A | N/A |
| Kineta, Inc. (YMTX) | 0.81% | $8.58M | -100.00% | N/A | N/A |
| Immuneering Corp. (IMRX) | 0.69% | $66.42M | N/A | N/A | N/A |
| Galecto, Inc. (GLTO) | 0.53% | $8.89M | N/A | N/A | N/A |